Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy

Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy

Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems, the interactions between components are often difficult or impossible to understand without the help of mathematical models. Mathematical models of cardiac ...

Cardiac Simulation to Personalize Cardiac Resynchronization Therapy.

Computational Modeling for Cardiac Resynchronization Therapy.

Cardiac resynchronization therapy (CRT) is an effective treatment for heart failure (HF) patients with an electrical substrate pathology causing ventricular dyssynchrony. However 40-50% of patients do not respond to treatment. Cardiac modeling of the electrophysiology, electromechanics, and hemodynamics of the heart has been used to study mechanisms behind HF pathology and CRT response. Recentl...

Modeling Cardiac Ventricular Activation

We describe the microscopic and macroscopic level modeling of the cardiac activation in the realistic three-dimensional ventricles of the human heart. At the microscopic level, the subthreshold behaviour of the excitable elements (cells) is governed by a reaction-diffusion equation derived from the bidomain theory, while in the suprathreshold state the elements obey cellular automata rules. Eac...

modEling appliEd to cardiac rEsynchronization thErapy

conclUsion / 230 of the complex pathophysiologic and electromechanical factors that underlie mechanical dyssynchrony. The goal of this chapter is to present the development, from magnetic resonance imaging (MRI) and diffusion tensor (DT) MRI scans, of individualized three-dimensional (3D) image-based multiscale computational models of ventricular electromechanics that incorporate the deleteriou...